Familial hemophagocytic lymphohistiocytosis in a newborn presenting with recurrent fever and thrombocytopenia

Rong Yin, Hongsheng Wang, Zhihua Li, Yun Cao, Lin Yang, Huijun Wang, Bingbing Wu, Christopher Dandoy, Erika L. Stalets, Blachy J. Dávila Saldaña, Laishuan Wang, Wenhao Zhou


Familial hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disease with major difficulties of diagnosis and treatment, especially in the neonatal period (1-3). Early diagnosis and early treatment of HLH improves patients’ outcomes. Herein, we present a Familial HLH case and discuss the differential diagnosis and the cutting edge opinions of treatment by the experts in this area.