AB014. Dormant viruses activate during spaceflight—NASA investigates
Abstract

AB014. Dormant viruses activate during spaceflight—NASA investigates

Satish Mehta

Johnson Space Center, NASA, Houston, TX, USA

Correspondence to: Satish Mehta, PhD. Johnson Space Center, NASA Houston, TX, USA. Email: satish.k.mehta@nasa.gov; satishmeh@gmail.com.

Abstract: NASA astronauts endure weeks or even months exposed to microgravity and cosmic radiation besides extreme G forces of take-off and re-entry. Stressors like social separation, confinement and an altered sleep-wake cycle compound this physical challenge. During spaceflight there is a rise in secretion of stress hormones like cortisol and adrenaline, which are known to suppress the immune system. In keeping with this, astronaut’s immune cells become less effective during spaceflight and sometimes for up to 60 days after. In the midst of this stress-induced amnesty on viral killing, dormant viruses reactivate and resurface. To study the physiological impact of spaceflight, we analyze saliva, blood and urine samples collected from astronauts before, during and after spaceflight. Herpes viral reactivation is evident through the shedding of viral DNA in the body fluids of astronauts, and the viral load only increases with more time in space. Herpes viruses reactivate in more than half of crew aboard Space Shuttle and International Space Station missions. While only a small proportion develop symptoms, virus reactivation rates increase with spaceflight duration and could present a significant health risk on missions to Mars and beyond. Our spaceflight-developed technologies for saliva collection/rapid viral detection have been extended to include clinical applications including zoster patients, chicken pox, post herpetic neuralgia (PHN), multiple sclerosis, and various neurological disorders. These protocols are employed in various clinics and hospitals including the CDC and Colombia University in New York, as well as overseas in Switzerland (Ricklin et al. 2013) and Israel (Pollack et al. 2015). In fact, we at NASA, developed a rapid and sensitive virus detection method that can detect virus in saliva samples from asymptomatic patients with neurologic and other VZV related disease before even the rash develops (Mehta et al. 2013).

Keywords: Dormant viruses; reactivation; spaceflight


doi: 10.21037/pm.2020.AB014
Cite this abstract as: Mehta S. Dormant viruses activate during spaceflight—NASA investigates. Pediatr Med 2020;3:AB014.