AB004. The role of highly active antiretroviral therapy (HAART) on interleukin 17a (il-17a) in normotensive and pre-eclamptic black South African women
Abstract

AB004. The role of highly active antiretroviral therapy (HAART) on interleukin 17a (il-17a) in normotensive and pre-eclamptic black South African women

Wendy N. Phoswa1, Thajasvarie Naicker2, Veron Ramsuran3,4, Jagidesa Moodley5

1Discipline of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, 2Optics and Imaging Centre, 3KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 4Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; 5Women’s Health and HIV Research Group, University of KwaZulu-Natal, Durban, South Africa

Correspondence to: Wendy N. Phoswa, BMedSc; MMedSci. Discipline of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Email: phoswawendy@gmail.com.

Background: Interleukin 17-A (IL-17A) has been implicated in the pathophysiology of both human immune deficiency virus (HIV) and preeclampsia (PE). This study evaluated serum levels of IL-17A in HIV-negative and HIV-positive normotensive and preeclamptic women receiving highly active anti -retroviral therapy (HAART).

Methods: A sample size of 250 was analysed. Normotensives (n=150; N), pre-eclamptics (n=100; PE). Normotensives were further stratified into HIV negative (n=90), HIV positive (HAART: acute) (n=30) and HIV positive (HAART: chronic) (n=30). The PE group was divided into early onset (n=50; EOPE) and late-onset (n=50; LOPE). The EOPE and LOPE groups were subdivided into HIV negative (n=30), HIV positive (HAART: acute) (n=10), and HIV positive (HAART: chronic) (n=10). Analysis of IL-17A was performed using multiple Bio-Plex immunoassay method.

Results: With regards: (I) pregnancy type: the levels of IL-17A were significantly increased in N compared to PE (P=0.0012); (II) gestational age: the levels of IL-17A were significantly different between (N vs. EOPE vs. LOPE) (P=0.0044). The levels of IL-17A were significantly increased in N compared to the EOPE (P=0.0113) and between N compared to the LOPE (P= 0.0063); (III) HIV status: the levels of IL-17A were significantly increased in HIV negative N compared to LOPE (P= 0.0429). (IV) HAART duration. HAART-chronic: the levels of IL-17A were significantly increased in (N vs. PE) (P=0.0086), (N vs. EOPE vs. LOPE) (P= 0.0179) and N vs. EOPE (P=0.0042).

Conclusions: The study demonstrates that IL-17A is involved in maintaining normal pregnancy and that reduction in IL-17A is involved in the pathophysiology of PE.

Keywords: Highly active antiretroviral therapy (HAART); human immunodeficiency virus; interleukin; pre-eclampsia; pregnancy


doi: 10.21037/pm.2020.AB004
Cite this abstract as: Phoswa WN, Naicker T, Ramsuran V, Moodley J. The role of highly active antiretroviral therapy (HAART) on interleukin 17a (il-17a) in normotensive and pre-eclamptic black South African women. Pediatr Med 2020;3:AB004.