Risk factors for necrotizing enterocolitis associated mortality

Yiyong Fu, Rong Ju, Guang Yue, Tiantian Xiao, Xiaolong Zhang, Shuqiang Gao, Yang Liu, Xuhong Hu


Background: Necrotizing enterocolitis (NEC) is one of the most devastating diseases in neonates, the risk factors related to NEC associated mortality are unclear. This study is aimed to confirm the risk factors for NEC associated mortality, which may help to early recognize patients who have death risk, to develop strategies to reduce NEC associated mortality.
Methods: The retrospective case-control study was performed in our center. Infants diagnosed confirmed NEC were included. Demographic and clinical data were collected. Univariate analysis and multivariate analysis were used to identify the risk factors of NEC associated mortality in this case-control cohort.
Results: A total of 163 infants were included in our study. In this cohort, univariate analysis showed gestational age (GA), birth weight (BW), 5-min Apgar score, leukopenia, thrombocytopenia, highest C-reaction protein (CRP) value, Duke abdominal assessment scale (DAAS), the necrotic range of intestine to be associated with an increased risk of mortality. In a multivariable logistic regression model, thrombocytopenia remained a risk factor statistically significantly for NEC associated mortality.
Conclusions: Thrombocytopenia in NEC infants was associated with an increased risk of mortality. In surgical patients, the greater range of intestine necrosis was associated with an increased risk of mortality, but intestinal perforation or no perforation was not related to mortality.