*, mutations in multiple genes cause congenital hypothyroidism (CH). The most common cause of CH worldwide is thyroid dysgenesis (85%) followed by dyshormonogenesis (10–15%). CH commonly causes mental retardation in Sudan because of lack of neonatal screening. It was reported that the predominant etiology of CH in the Sudan was dyshormonogenesis (62%), however the genetic cause is unreported.
Cite this article as: Shareef R, Watanabe Y, Creech MK, Bis DM, Züchner S, Abdullah MA, Dumitrescu AM, Refetoff S, Weiss RE. *Genetic analysis of 11 Sudanese families with congenital hypothyroidism. Pediatr Med 2018;1:AB022.